1041 Impact of Spectral Contamination and Anatomical Location on Diagnostic Accuracy of Single-Voxel Spectroscopy in Pre-Operative Glioma Characterisation
نویسندگان
چکیده
Abstract Aim Single-voxel spectroscopy (SVS) discriminates amongst brain tumours by measuring metabolite variations reflective of malignant transformation. However, spectral contamination may affect diagnostic accuracy, impacting radiological opinion regions interest (ROI) required to determine extent surgical resection. Method A single-centre, retrospective, observational study, including 93 SVS meaningfully interpretable examinations between 2012 and 2018. Accuracy lesion classification was assessed comparison histological diagnosis as reference standards against discrimination entities tumour grades SVS, with consideration for voxel location, volume, proximity the calvaria or ventricular system. Quantification metabolites recorded ratios, visual inspection, qualitative descriptive analysis were undertaken. Results demonstrated high entity accuracy (100%) but lower grade (87%), ranging from periventricular (73%) vs non-periventricular (90%), subcalvarial (86%) subcortical (88%) voxels. CSF caused dilution and/or enhanced lactate signals sub-arachnoid CSF, especially in areas increased brain-skull distance; lipid peri-calvarial fat subcutaneous tissue resulted neighbouring brain-scalp distance. Misclassified lesions located cranial concavity, reduced cerebral cortical thickness inappropriate outer volume suppression (OVS). Voxel variation had no impact across coordinates (p=0.605), (p=0.127) (p=0.367). Conclusion Spectral significantly impacted enhance lipids leading under- overestimation glioma grade, respectively, thus indicating that avoidance contaminating tissues OVS are pivotal adequate quality accuracy.
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2022
ISSN: ['1365-2168', '0007-1323']
DOI: https://doi.org/10.1093/bjs/znac269.281